49ers vs Vikings Best Bets, Odds for Monday Night Football
| 49ers Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-7 Even | 44 -110o / -110u | -310 |
| Vikings Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+7 -120 | 44 -110o / -110u | +250 |
Week 7 concludes with a Monday Night Football matchup at U.S. Bank Stadium, and our NFL betting analysts are all over it with 49ers vs Vikings best bets on picks, player props and more.
The 49ers vs Vikings spread has San Francisco installed at -7 with a game total of 44 across most books (FanDuel is offering 43.5). We have two bettors backing the Vikings to cover the spread (+7), plus two prop picks for Brandon Aiyuk (receiving yards and Anytime Touchdown).
Our staff of NFL analysts are all over this game with this MNF betting preview. From 49ers vs Vikings spread picks to player props, here are our experts' four best bets for Monday Night Football.
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Monday Night Football Best Bets: NFL Player Props, Picks Against Spread
The team logos in the table below represent each of the matchups that our NFL betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
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Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
49ers vs. Vikings
Brock Purdy is just 2-4 against the spread on the road in his career, and over the last 20 years in total, primetime road favorites of seven or more points have covered just 44.1% of the time.
Purdy will be without left tackle Trent Williams and wide receiver Deebo Samuel. San Francisco will be facing a Vikings defense that has shown signs of improvement, now up to the 12th-best unit in the league in yards per play allowed at 4.9. The Vikings are going to stay aggressive, bringing extra rushers to test a 49ers' offensive line missing arguably the best tackle in football in Williams.
Teams have defeated the Vikings blitz by getting the ball out quickly with passes that have averaged just 6.4 yards per attempt, which is the second-lowest mark in the league against blitzing defenses. The 49ers offense will not be able to mimic this blueprint successfully without their best YAC weapon in Samuel.
I like this spot for the Vikings in another near-must-win game for them defending home turf. Despite 80% of the tickets tracked in the Action App being on the 49ers, the line continues to move toward the Vikings. I am comfortable playing -7 at -120 or lower. Otherwise, play the home team down to +6.
Pick: Vikings +7 (-120; Bet to +6)
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49ers vs. Vikings
By Kevin Rogers
San Francisco is back on the road and looking to bounce back from its first loss of the season last week at Cleveland. The 49ers face a Vikings team that has stumbled to a 2-4 start.
Both teams are missing their star wide receivers — Minnesota's Justin Jefferson is sidelined with a hamstring injury while San Francisco's Deebo Samuel is dealing with a shoulder injury.
The Vikings are coming off their second win of the season as they held off the Bears, 19-13, as three-point road favorites. Minnesota has yet to win a game at U.S. Bank Stadium this season, posting an 0-3 home mark with all losses coming by seven points or fewer.
Four of San Francisco's first five wins came by 18 points or more, but the 49ers were stifled by the Browns in a 19-17 defeat as 8.5-point road favorites. San Francisco led 10-0 early but mustered only 215 yards of offense and running back Christian McCaffrey exited with an oblique injury.
Without Jefferson, the Vikings are missing their biggest offensive piece, but Minnesota has hung with the likes of Philadelphia and Kansas City in close losses.
San Francisco is in bounce-back mode, but quarterback Brock Purdy hasn't thrown for more than 220 yards in any of his three road games this season.
Let's back the home team with the points in this NFC showdown.
Pick: Vikings +7
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49ers vs. Vikings
Aiyuk has been really solid this season, and he should be in for a decent workload in this spot.
Samuel is already out, but Christian McCaffrey looks like he's going to play. Samuel's absence will mean a big uptick for Aiyuk, and the books clearly haven't adjusted enough.
Aiyuk has been putting up great numbers, with almost 100 yards receiving per game. He has hit the over on this total in three of five games this season with one of those two misses coming because of a massive blowout vs. Dallas.
I have Aiyuk projected for over 85 yards, and that might be a little low. While George Kittle will likely eat up some of the extra usages in Samuel's absence, Aiyuk is going to be the guy here in this passing game.
I would hit this line all the way up to 80 yards.
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49ers vs. Vikings
There will be no Samuel, and McCaffrey will enter Monday Night Football banged up but expected to play. Either way, this is an amazing matchup for Aiyuk.
Minnesota rolls out primarily zone coverage, and that's where Aiyuk shines. Aiyuk has a 29.9% target share, and his first-read share jumps all the way up to 36.4% against zone coverage. These numbers are all with Samuel in the lineup, so he should have a bigger role and a huge game in primetime.
I really like Aiyuk's reception prop, but it's pretty juiced (-155) so yards are another way to go, as Grant laid out above. Instead, I'll bank on Purdy finding his key playmaker in the passing game against a bad pass defense for a score.
Pick: Brandon Aiyuk Anytime Touchdown Scorer (+145)
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